Quorum Sensing Blocking - the solution

Preventing biofilm is a novel approach to microbial control - the ability to disrupt the processes leading to biofilm formation will have potential for beneficial effect across a broad spectrum of indications in human healthcare as well as applications in the consumer and industrial environment. There is an urgent need for a novel, safe technology to achieve this.

QuoNova is developing its selective quorum sensing blockers (QSBs) which, by disrupting the quorum sensing signaling mechanism, render bacteria less harmful and prevent biofilm growth.

These molecules are not biocidal, and should therefore reduce the selection pressure towards the development of resistance in bacterial strains. Moreover these compounds synergize with antibiotics, and are effective by multiple routes of administration, including incorporation in different matrices where they inhibit surface biofilm growth. Different molecules have been shown to be active against a range of clinically and industrially relevant bacteria.

QuoNova's novel QSB platform technology consists of various classes of small molecules identified by structure based drug design. These molecules interact with the transcriptional receptor with high affinity resulting in inactivation of the QS blocker-receptor complex. In all studies to date they have been shown to be safe and non-toxic.

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